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　　原标题：肉类过敏及其过敏原
　　IgE介导的对摄入动物产品(包括哺乳动物和禽类)的超敏反应日益被认为是一种重要的食物过敏形式。传统上主要描述儿童的情况，现在很清楚，对肉类(和动物内脏)的过敏影响儿童和成人，代表了一个异质性的过敏性疾病群体，有多种不同的综合征。随着对猪猫综合症和迟发性红肉过敏等的认识，例如α-半乳糖综合症，其基本原理, 以及一些最近得到关注的病例的过敏特征已经被搞清。包括对暴露途径和致敏机制的深入了解，以及认识到IgE介导的反应可延迟数小时。在此，我们回顾了对哺乳动物和禽类的肉过敏，重点介绍了导致疾病的分子过敏原和途径，以及体外IgE检测在诊断和管理中的作用。
延伸阅读
Molecular Immunology  Volume 100, August 2018, Pages 107-112
Meat allergy and allergens
https://doi.org/10.1016/j.molimm.2018.03.018
Abstract:
Abstract
IgE-mediated hypersensitivity to ingested animal products, including both mammalian and avian sources, is increasingly appreciated as an important form of food allergy. Traditionally described largely in children, it is now clear that allergy to meat (and animal viscera) impacts both children and adults and represents a heterogeneous group of allergic disorders with multiple distinct syndromes. The recognition of entities such as pork-cat syndrome and delayed anaphylaxis to red meat, i.e- the α-Gal syndrome, have shed light on fundamental, and in some cases newly appreciated, features of allergic disease. These include insights into routes of exposure and mechanisms of sensitization, as well as the realization that IgE-mediated reactions can be delayed by several hours. Here we review mammalian and avian meat allergy with an emphasis on the molecular allergens and pathways that contribute to disease, as well as the role of in vitro IgE testing in diagnosis and management.
All Authors:
Jeffrey M.WilsonThomas A.E.Platts-Mills
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。