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Release date：2018-11-13

Clinical & Experimental Allergy

[IF:5.158]

Sensitisation to minor cat allergen components is associated with type-2 biomarkers in young asthmatics
DOI: 10.1111/cea.13135
Abstract:
Background: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisationvary between individuals, but their relationship to inflammation in asthmatics has not beenextensively studied.
Methods: Patients with asthma (age 10−35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins). Independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analysed by multiple linear regression after adjustment for possible confounders.
Results: The level of IgE against Fel d 2 was independently related to FeNO (p=0.012) and total IgE (p<0.001), and IgE against Fel d 4 associated with Β-Eos count (p=0.009) and total IgE (p<0.001). IgE antibodies against Fel d 1 or cat extract did not independently relate to these inflammatory markers (p=0.23−0.51).
Conclusions: Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were independently associated with type-2 biomarkers and total IgE in young asthmatics.
First Author:
Tsolakis N.
Correspondence:
Department of Women’s and Children’s Health, Uppsala University
All Authors:
Tsolakis N, Malinovschi A, Nordvall L, Mattsson L, Lidholm J, Pedroletti C, Janson C, Borres M.P, and Alving K

2018-10-25 Article